BOS-172722

Product Specifications

UNSPSC Description

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1].

Target Antigen

Mps1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BOS-172722.html

Purity

98.65

Solubility

1M HCl : 65 mg/mL (ultrasonic;adjust pH to 2 with HCl)|DMSO : < 1 mg/mL

Smiles

CC1=CC2=CN=C(NC3=CC=C(C4=NN=CN4C)C=C3OCC)N=C2C(NCC(C)(C)C)=N1

Molecular Weight

446.55

References & Citations

[1]ARYL SULFONOHYDRAZIDES. WO 2014037750 A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-112162/BOS-172722-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-112162/BOS-172722-SDS-MedChemExpress.pdf

Clinical Information

Phase 1

CAS Number

1578245-44-9

Available Sizes

Curated Selection

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