BOS-172722
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer[1].
Product Specifications
CAS Number
[1578245-44-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BOS-172722.html
Purity
98.65
Solubility
1M HCl : 65 mg/mL (ultrasonic; adjust pH to 2 with HCl) |DMSO : < 1 mg/mL
Smiles
CC1=CC2=CN=C(NC3=CC=C(C4=NN=CN4C)C=C3OCC)N=C2C(NCC(C)(C)C)=N1
Molecular Formula
C24H30N8O
Molecular Weight
446.55
Precautions
H302, H315, H319, H335
References & Citations
[1]ARYL SULFONOHYDRAZIDES. WO 2014037750 A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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