TCO-PEG8-NHS ester
Product Specifications
UNSPSC Description
TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG8-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg8-nhs-ester.html
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Molecular Weight
690.78
References & Citations
[1]Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141169/TCO-PEG8-NHS-ester-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141169/TCO-PEG8-NHS-ester-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2353409-95-5
Available Sizes
Curated Selection
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