Meta-Fexofenadine-d6

Meta-Fexofenadine-d6 is the deuterium labeled meta-Fexofenadine. meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine[1]. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial[2].

Product Specifications

Product Name Alternative

Meta-MDL-16455-d6; meta-Terfenadine carboxylate-d6

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C(O)C(C([2H])([2H])[2H])(C1=CC(C(O)CCCN2CCC(CC2)C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=CC=C1)C([2H])([2H])[2H]

Molecular Formula

C32H33D6NO4

Molecular Weight

507.69

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Maher HM, et al. Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets. Chem Cent J. 2011 Dec 3;5 (1) :76.|[3]Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4 (3) :367-75.