Ankaflavin

Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects[1][2].

Product Specifications

CAS Number

[50980-32-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; PPAR

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ankaflavin.html

Purity

98.22

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1C(CCCCCCC)=O)O[C@]2(C)[C@]1([H])CC(C=C(/C=C/C)OC3)=C3C2=O

Molecular Formula

C23H30O5

Molecular Weight

386.48

Precautions

H302, H315, H319

References & Citations

[1]Su NW, et al. Ankaflavin from Monascus-fermented red rice exhibits selective cytotoxic effect and induces cell death on Hep G2 cells. J Agric Food Chem. 2005 Mar 23;53 (6) :1949-54.|[2]Lee BH, et al. Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. Free Radic Biol Med. 2012 Dec 1;53 (11) :2008-16.