Rho-Kinase-IN-3
Rho-Kinase-IN-3 (compound 12) is a potent and selective Rho kinase (ROCK1) inhibitor with an IC50 value of 8 nM. Rho-Kinase-IN-3 can be used in research of hypertension[1].
Product Specifications
CAS Number
[864082-23-5]
Product Name Alternative
BMS 234303-01
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rho-kinase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(C=C1)NN=C2)C(C(CC3=O)C4=CC=C5C=CC=CC5=C4)=C(N3)C
Molecular Formula
C24H20N4O2
Molecular Weight
396.44
References & Citations
[1]Goodman KB, et, al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50 (1) :6-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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