Rho-Kinase-IN-3

Rho-Kinase-IN-3 (compound 12) is a potent and selective Rho kinase (ROCK1) inhibitor with an IC50 value of 8 nM. Rho-Kinase-IN-3 can be used in research of hypertension[1].

Product Specifications

CAS Number

[864082-23-5]

Product Name Alternative

BMS 234303-01

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rho-kinase-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC2=C(C=C1)NN=C2)C(C(CC3=O)C4=CC=C5C=CC=CC5=C4)=C(N3)C

Molecular Formula

C24H20N4O2

Molecular Weight

396.44

References & Citations

[1]Goodman KB, et, al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50 (1) :6-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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