Rho-Kinase-IN-3
Product Specifications
Product Name Alternative
BMS 234303-01
UNSPSC Description
Rho-Kinase-IN-3 (compound 12) is a potent and selective Rho kinase (ROCK1) inhibitor with an IC50 value of 8 nM. Rho-Kinase-IN-3 can be used in research of hypertension[1].
Target Antigen
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rho-kinase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(C=C1)NN=C2)C(C(CC3=O)C4=CC=C5C=CC=CC5=C4)=C(N3)C
Molecular Weight
396.44
References & Citations
[1]Goodman KB, et, al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118151/Rho-Kinase-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118151/
Clinical Information
No Development Reported
CAS Number
864082-23-5
Available Sizes
Curated Selection
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