Zaurategrast ethyl ester

Zaurategrast ethyl ester (CDP323), the ethyl ester proagent of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].

Product Specifications

CAS Number

[455264-30-9]

Product Name Alternative

CDP323; UCB1184197

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Zaurategrast_ethyl_ester.html

Purity

99.21

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C(OCC)[C@H](CC1=CC=C(NC2=NC=CC3=C2C=NC=C3)C=C1)NC4=C(Br)C(C45CCCCC5)=O

Molecular Formula

C28H29BrN4O3

Molecular Weight

549.46

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43 (9) :1381-91.|[2]Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12 (13-14) :569-76.