5'-N-Ethylcarboxamidoadenosine
5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.
Product Specifications
CAS Number
35920-39-9
Product Name Alternative
NECA
UNSPSC
12352005
Hazard Statement
H300
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/NECA.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@H](N2C=NC3=C(N)N=CN=C23)O[C@H](C(NCC)=O)[C@H]1O
Molecular Formula
C12H16N6O4
Molecular Weight
308.29
Precautions
H300
References & Citations
[1]Knapp CM, et al. Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol Biochem Behav. 2001 Apr;68 (4) :797-803.|[2]Elsherbiny NM, et al. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw. 2012 Jul-Sep;23 (3) :78-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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