5'-N-Ethylcarboxamidoadenosine

5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.

Product Specifications

CAS Number

[35920-39-9]

Product Name Alternative

NECA

UNSPSC

12352005

Hazard Statement

H300

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/NECA.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@H](N2C=NC3=C(N)N=CN=C23)O[C@H](C(NCC)=O)[C@H]1O

Molecular Formula

C12H16N6O4

Molecular Weight

308.29

Precautions

H300

References & Citations

[1]Knapp CM, et al. Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol Biochem Behav. 2001 Apr;68 (4) :797-803.|[2]Elsherbiny NM, et al. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw. 2012 Jul-Sep;23 (3) :78-86.