MHY1485
MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes[1].
Product Specifications
CAS Number
326914-06-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; mTOR
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MHY1485.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 7 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC=C(NC2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)[O-]
Molecular Formula
C17H21N7O4
Molecular Weight
387.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Gao L, et al. Glycochenodeoxycholate promotes hepatocellular carcinoma invasion and migration by AMPK/mTOR dependent autophagy activation. Cancer Lett. 2019 Jul 10;454:215-223.|[2]Choi YJ, et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS One. 2012;7 (8) :e43418.|[3]Zhou J, et al.Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells.Cell Death Dis. 2017 Aug 17;8 (8) :e3001.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTORC1; mTORC2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
ARP71063_P050 100 µL
OR4C11 Antibody - C-terminal region (ARP71063_P050)
Sign In for Pricing
View Details 
040330 200 µL
PPM1M, ID (PPM1M, PPM1E, Protein phosphatase 1M, Protein phosphatase 2C isoform eta)
Sign In for Pricing
View Details 
K6636404 1.0 µg DNA
Arhgef19 sgRNA CRISPR Lentivector (Rat) (Target 3)
Sign In for Pricing
View Details