What is the catalog number for CAD Antibody / CALD1 / Caldesmon (HMW)?

The catalog number for CAD Antibody / CALD1 / Caldesmon (HMW) is orb2641884.

What sizes are available for CAD Antibody / CALD1 / Caldesmon (HMW)?

CAD Antibody / CALD1 / Caldesmon (HMW) is available in the following size(s): 7 mL.

Is CAD Antibody / CALD1 / Caldesmon (HMW) in stock?

CAD Antibody / CALD1 / Caldesmon (HMW) is currently made to order / not held in immediate stock. Contact us for lead time.

CAD Antibody / CALD1 / Caldesmon (HMW)

Caldesmon is an actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments) . Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity) . [UniProt]

Product Specifications

UniProt

Q05682

Reactivity

Human

Immunogen

Recombinant full-length human protein was used as the immunogen for the CAD antibody.

Clonality

Monoclonal

Clone

CDSM-3

Conjugation

Unconjugated

Field of Research

Musculoskeletal & Connective Tissue Research

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Titering of the CAD antibody may be required for optimal performance.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.