DNA crosslinker 6
DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM) . In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei[1].
Product Specifications
CAS Number
272791-87-4
UNSPSC
12352211
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/dna-crosslinker-6.html
Smiles
O=C(NC1=CC=C(NC2=NCCN2)C=C1)C3=CC=C(NC4=NCCN4)C=C3
Molecular Formula
C19H21N7O
Molecular Weight
363.42
References & Citations
[1]Nué-Martinez J J, et al. Crystal structure of the HMGA AT-hook 1 domain bound to the minor groove of AT-rich DNA and inhibition by antikinetoplastid drugs[J]. Scientific Reports, 2024, 14 (1) : 26173.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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