U7D-1
U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC50 of 33 nM in RS4;11 cells. U7D-1 shows anticancer activity. U7D-1 induces apoptosis in Jeko-1 cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Deubiquitinase; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/u7d-1.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCCCCCCNCC4=CC=C(C5=C(C6=NN5C)N=CN(CC7(O)CCN(C(C[C@H](C8=CC=CC=C8)C)=O)CC7)C6=O)C=C4)=O
Molecular Formula
C53H65N9O7
Molecular Weight
940.14
References & Citations
[1]Pei Y, et al. Discovery of a Potent and Selective Degrader for USP7. Angew Chem Int Ed Engl. 2022 Aug 15;61 (33) :e202204395.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Acid Phosphatase (ACP1) (NM_004300) Human Recombinant Protein
![APC Mouse IgG1, κ Isotype Control[MOPC-21]](https://cdn.genprice.uk/products/763/68dd14a3061270361e7d10f7/imageurl/e-ab-f09792e.webp)
APC Mouse IgG1, κ Isotype Control[MOPC-21]