U7D-1
U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC50 of 33 nM in RS4;11 cells. U7D-1 shows anticancer activity. U7D-1 induces apoptosis in Jeko-1 cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Deubiquitinase; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/u7d-1.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCCCCCCNCC4=CC=C(C5=C(C6=NN5C)N=CN(CC7(O)CCN(C(C[C@H](C8=CC=CC=C8)C)=O)CC7)C6=O)C=C4)=O
Molecular Formula
C53H65N9O7
Molecular Weight
940.14
References & Citations
[1]Pei Y, et al. Discovery of a Potent and Selective Degrader for USP7. Angew Chem Int Ed Engl. 2022 Aug 15;61 (33) :e202204395.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7
Available Sizes
Frequently Asked Questions
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