Org 48762-0
Org 48762-0 (UR13870) is a potent, orally active and selective p38 inhibitor with an EC50 of 0.1 μM for p38α kinase. Org 48762-0 shows a high degree of kinase selectivity for p38α and p38β over other kinases. Org 48762-0 reduces Lipopolysaccharides (LPS) -induced TNFα release. Org 48762-0 can be used for the study of rheumatoid arthritis (RA) and Werner syndrome[1][2].
Product Specifications
CAS Number
755753-89-0
Product Name Alternative
UR13870
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/org-48762-0.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1N=C2C(C(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)C(C5=CC=C(F)C=C5)=N2)=C1
Molecular Formula
C24H16F2N4
Molecular Weight
398.41
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α
Available Sizes
Frequently Asked Questions
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