What is the catalog number for CD21 Antibody?

The catalog number for CD21 Antibody is orb2641445.

What sizes are available for CD21 Antibody?

CD21 Antibody is available in the following size(s): 7 mL.

Is CD21 Antibody in stock?

CD21 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

CD21 Antibody

Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2) /CD21. Its epitope is located in 5-8 short consensus repeats (SCRs) . This mAb is highly specific to CR2 and shows no cross-reaction with CR1. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

Product Specifications

UniProt

P20023

Reactivity

Human

Immunogen

A portion of amino acids 142-240 from the human protein was used as the immunogen for the CD21 antibody.

Clonality

Monoclonal

Clone

CR2/2754

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the CD21 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.