What is the catalog number for Recombinant Integrin beta 3 Antibody / ITGB3 / CD61?

The catalog number for Recombinant Integrin beta 3 Antibody / ITGB3 / CD61 is orb2640567.

What sizes are available for Recombinant Integrin beta 3 Antibody / ITGB3 / CD61?

Recombinant Integrin beta 3 Antibody / ITGB3 / CD61 is available in the following size(s): 7 mL.

Is Recombinant Integrin beta 3 Antibody / ITGB3 / CD61 in stock?

Recombinant Integrin beta 3 Antibody / ITGB3 / CD61 is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant Integrin beta 3 Antibody / ITGB3 / CD61

Reacts with human Integrin beta 3, also called CD61. It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alpha-IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61) . The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Product Specifications

UniProt

P05106

Reactivity

Human

Immunogen

Human recombinant protein was used as the immunogen for the recombinant Integrin beta 3 antibody.

Clonality

Recombinant

Clone

ITGB3/2166R

Conjugation

Unconjugated

Field of Research

Neuroscience; Immunology & Inflammation

Purification

Protein A affinity

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Titration of the recombinant Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.