What is the catalog number for TTF-1 Antibody / NKX2.1?

The catalog number for TTF-1 Antibody / NKX2.1 is orb2639265.

What sizes are available for TTF-1 Antibody / NKX2.1?

TTF-1 Antibody / NKX2.1 is available in the following size(s): 7 mL.

Is TTF-1 Antibody / NKX2.1 in stock?

TTF-1 Antibody / NKX2.1 is currently made to order / not held in immediate stock. Contact us for lead time.

TTF-1 Antibody / NKX2.1

Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1, also called NKX2.1. TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Product Specifications

UniProt

P43699

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein was used as the immunogen for the TTF-1 antibody.

Clonality

Monoclonal

Clone

NX2.1/690

Conjugation

Unconjugated

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the TTF-1 antibody should be determined by the researcher.1. Staining of formalin/paraffin tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.