Calgranulin A + B Antibody
Recognizes a 12-14kDa doublet of Calgranulin A/B (also known as S100A8/A9 or MRP-8/14) ; expressed by granulocytes, monocytes and by tissue macrophages. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of this protein is associated with the disease cystic fibrosis. This mAb reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and has been shown as an important marker for identifying macrophages in tissue sections.
Product Specifications
UniProt
P06702
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the Calgranulin A + B antibody.
Clonality
Monoclonal
Clone
CAGB/426
Conjugation
Unconjugated
Purification
PEG precipitation
Dilution
Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgM, kappa
Frequently Asked Questions
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