TK05
TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].
Product Specifications
CAS Number
1245734-61-5
UNSPSC
12352005
Target
Glutathione S-transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tk05.html
Concentration
10mM
Purity
97.05
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=CC=C(N(CC2CC2)C3=CC=C(C(C4=CC(C(O)=O)=C(C(C5=CC=C(OC)C=C5)=O)C=C4)=O)N=C3)C=C1
Molecular Formula
C31H25ClN2O5
Molecular Weight
540.99
References & Citations
[1]Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355 (1) :108-16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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