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FGF-23 Antibody / Fibroblast Growth Factor 23

Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the family include the oncogenes FGF3 (Int2) and FGF4 (hst/Kaposi), FGF5, FGF6, FGF7 (KGF), FGF8 (AIGF), FGF9 (GAF) and FGF10 through FGF-23. Members of the family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in trans- fected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Product Specifications

Reactivity

Human

Immunogen

A recombinant human FGF-23 protein was used as the immunogen for this antibody.

Clonality

Monoclonal

Clone

FGF23/638

Conjugation

Unconjugated

Field of Research

Stem Cell & Developmental Biology

Purification

Protein G purified

Dilution

ELISA: order BSA/sodium azide-free format for coating, Functional studies: order BSA/sodium azide-free format

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FGF-23 antibody to be titered up or down for optimal performance.

Tested Applications

ELISA, Functional Studies

Host or Source

Mouse

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Mouse IgG1, kappa

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