Nk1.1 Antibody / Cd161c
NK-1.1 is commonly used as a mouse NK cell marker. It has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. It is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by the Klrb1c/NKR-P1C gene. It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1.1 is expressed in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo.
Product Specifications
UniProt
P27814
Reactivity
Mouse
Immunogen
Mouse spleen and bone marrow cells enriched for NK-1+ cells were used as the immunogen for the Nk1.1 antibody.
Clonality
Monoclonal
Clone
PK136
Conjugation
Unconjugated
Purification
Protein A/G affinity
Dilution
Flow cytometry: 0.5-1ug/million cells in 0.1ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Nk1.1 antibody should be determined by the researcher.
Tested Applications
FACS
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2a, kappa
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