ARL 17477
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers[1].
Product Specifications
CAS Number
[866914-87-6]
UNSPSC
12352005
Hazard Statement
H302, H319
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arl-17477.html
Purity
99.02
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
[H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2
Molecular Formula
C20H22Cl3N3S
Molecular Weight
442.83
Precautions
H302, H319
References & Citations
[1]Teiko Komori Nomura, et al. ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Sci Rep. 2023 Jul 4;13 (1) :10757.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
041364-ML490 100 µL
S1PR2, CT (S1PR2, EDG5, Sphingosine 1-phosphate receptor 2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5) (MaxLight 490) discontinued
Ask
View Details 
LS010647-20ug 20 µg
Lipophilin B (SCGB1D2) (NM_006551) Human Over-expression Lysate
Ask
View Details