ARL 17477
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers[1].
Product Specifications
CAS Number
[866914-87-6]
UNSPSC
12352005
Hazard Statement
H302, H319
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arl-17477.html
Purity
99.02
Solubility
DMSO : 62.5 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
[H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2
Molecular Formula
C20H22Cl3N3S
Molecular Weight
442.83
Precautions
H302, H319
References & Citations
[1]Teiko Komori Nomura, et al. ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Sci Rep. 2023 Jul 4;13 (1) :10757.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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