ARL 17477

ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers[1].

Product Specifications

CAS Number

[866914-87-6]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/arl-17477.html

Purity

99.02

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

[H]Cl.[H]Cl.N=C(C1=CC=CS1)NC2=CC=C(CCNCC3=CC(Cl)=CC=C3)C=C2

Molecular Formula

C20H22Cl3N3S

Molecular Weight

442.83

Precautions

H302, H319

References & Citations

[1]Teiko Komori Nomura, et al. ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Sci Rep. 2023 Jul 4;13 (1) :10757.