CNOT10 Antibody / CCR4-NOT transcription complex subunit 10
CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome.
Product Specifications
UniProt
Q9H9A5
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CNOT10 antibody.
Clonality
Monoclonal
Clone
PCRP-CNOT10-1D5
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein A/G affinity
Dilution
ELISA (order BSA-free format for coating), Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2ug/ml, Western blot: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CNOT10 antibody should be determined by the researcher.
Tested Applications
ELISA, FACS, IF, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG2c
Available Sizes
Frequently Asked Questions
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