Atm (Acetyl Lys316) rabbit pAb
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],
Product Specifications
Background
Synonyms
Serine-protein kinase ATM (EC 2.7.11.1;Ataxia telangiectasia mutated;A-T mutated)
Gene ID
472
UniProt
Q13315
Cellular Locus
Host
Rabbit
Species Reactivity
Human,Rat,Mouse
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human Atm (Acetyl Lys316)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Molecular Weight
330kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20056-1.pdf
Observed Molecular Weight
330 kD
Subcellular Location
Other Product Names
Serine-protein kinase ATM (EC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutated)
Gene ID (Human)
472
SwissProt (Human)
Q13315
Available Sizes
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