Recombinant SOX2 Antibody
SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.
Product Specifications
UniProt
P48431
Reactivity
Human, Mouse
Immunogen
A recombinant human partial protein (amino acids 176-305) was used as the immunogen for the recombinant SOX2 antibody.
Clonality
Recombinant
Clone
SOX2/3169R
Conjugation
Unconjugated
Field of Research
Stem Cell & Developmental Biology
Purification
Protein A affinity chromatography
Dilution
ELISA (order BSA-free format for coating), Western blot: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant SOX2 antibody should be determined by the researcher.
Tested Applications
ELISA, IHC-P, WB
Host or Source
Rabbit
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Rabbit IgG, kappa
Frequently Asked Questions
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