FCGRT Antibody / FcRn
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.
Product Specifications
UniProt
P55899
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 24-215) was used as the immunogen for the FCGRT antibody.
Clonality
Monoclonal
Clone
FCGRT/2932
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the FCGRT antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa
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