Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

VU0359595

VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 μM) . VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases[1][2][3][4].

Product Specifications

CAS Number

1246303-14-9

Product Name Alternative

CID-53361951; ML-270

UNSPSC

12352005

Target

Fungal; Phospholipase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0359595.html

Purity

98.06

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C([C@H]1[C@H](C2=CC=CC=C2)C1)N[C@@H](C)CN3CCC(N4C5=CC=C(Br)C=C5NC4=O)CC3

Molecular Formula

C25H29BrN4O2

Molecular Weight

497.43

References & Citations

[1]Burkhardt U, et al. Phospholipase D is a target for inhibition of astroglial proliferation by ethanol. Neuropharmacology. 2014;79:1-9.|[2]Tenconi PE, et al. High glucose-induced phospholipase D activity in retinal pigment epithelium cells: New insights into the molecular mechanisms of diabetic retinopathy. Exp Eye Res. 2019;184:243-257.|[3]Bermúdez V, et al. Lipopolysaccharide-Induced Autophagy Mediates Retinal Pigment Epithelium Cells Survival. Modulation by the Phospholipase D Pathway. Front Cell Neurosci. 2019;13:154. Published 2019 Apr 24.|[4]Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009;19 (7) :1916-1920.|[5]Jia X, et al. Gliotoxin promotes Aspergillus fumigatus internalization into type II human pneumocyte A549 cells by inducing host phospholipase D activation. Microbes Infect. 2014 Jun;16 (6) :491-501.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PLD

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

FUT3 (NM_000149) Human Over-expression Lysate
LC424899 20 µg

FUT3 (NM_000149) Human Over-expression Lysate

Sign In for Pricing
View Details
Lect2 (NM_010702) Mouse Tagged ORF Clone
MG201087 10 µg

Lect2 (NM_010702) Mouse Tagged ORF Clone

Sign In for Pricing
View Details
PE Anti-Mouse CD119 Antibody[GR-20]
E-AB-F1115UD-01 25 µg

PE Anti-Mouse CD119 Antibody[GR-20]

Sign In for Pricing
View Details
PE Anti-Mouse CD119 Antibody[GR-20]
E-AB-F1115UD-02 100 µg

PE Anti-Mouse CD119 Antibody[GR-20]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Human CD1a Antibody[OKT-6]
E-AB-F1126M-01 20 Tests

Elab Fluor® 647 Anti-Human CD1a Antibody[OKT-6]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Human CD1a Antibody[OKT-6]
E-AB-F1126M-02 100 Tests

Elab Fluor® 647 Anti-Human CD1a Antibody[OKT-6]

Sign In for Pricing
View Details