What is the catalog number for MDM2 Antibody?

The catalog number for MDM2 Antibody is orb2642192.

What sizes are available for MDM2 Antibody?

MDM2 Antibody is available in the following size(s): 7 mL.

Is MDM2 Antibody in stock?

MDM2 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

MDM2 Antibody

MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.

Product Specifications

UniProt

Q00987

Reactivity

Human

Immunogen

A portion of amino acids 126-254 was used as the immunogen for the MDM2 antibody.

Clonality

Monoclonal

Clone

MDM2/2414

Conjugation

Unconjugated

Field of Research

Cell Biology

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the MDM2 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.