IFNA1 Antibody / Interferon alpha 1
This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- Receptor (IFNAR1) . Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
Product Specifications
UniProt
P01562
Reactivity
Human
Immunogen
Purified recombinant human protein was used as the immunogen for the Interferon alpha antibody.
Clonality
Monoclonal
Clone
2.48
Conjugation
Unconjugated
Field of Research
Infectious Disease & Virology; Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Western blot: 1-2ug/ml, Immunofluorescence: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the IFNA1 antibody should be determined by the researcher.
Tested Applications
FACS, IF, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa
Frequently Asked Questions
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