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Capsaicin

Product Specifications

UNSPSC Description

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects[1][2].

Target Antigen

Apoptosis; Autophagy; Endogenous Metabolite; TRP Channel

Type

Natural Products

Related Pathways

Apoptosis;Autophagy;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Capsaicin.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)

Smiles

CC(C)/C=C/CCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Molecular Weight

305.41

References & Citations

[1]McNamara FN, et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol. 2005 Mar;144(6):781-90.|[2]Shin YH, et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21(7).|[3]Anandakumar P, et al. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17(2):254-259.|[4]Nah JJ, et al. Effect of ginsenosides, active components of ginseng, on capsaicin-induced pain-related behavior. Neuropharmacology. 2000 Aug 23;39(11):2180-4.|[5]Joshi SK, et al Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity. Neuroscience. 2006 Dec 1;143(2):587-96.|[6]Pelissier T, et al. The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine. Pain. 2002 Mar;96(1-2):81-7.|[7]Matsuda H, et al. Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci. 1999;65(2):PL27-32.|[8]Demirbilek S, et al. Small-dose capsaicin reduces systemic inflammatory responses in septic rats. Anesth Analg. 2004 Nov;99(5):1501-1507.|[9]Friedman JR, et al. Anticancer Activity of Natural and Synthetic Capsaicin Analogs. J Pharmacol Exp Ther. 2018 Mar;364(3):462-473.|[10]Glinsukon T, et al. Acute toxicity of capsaicin in several animal species[J]. Toxicon, 1980, 18(2): 215-220.|[11]Kawada T, Iwai K. In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper [Capsicum annuum], in rats[J]. Agricultural and Biological Chemistry (Japan), 1985, 49(2).|[12]Saito A, Yamamoto M. Acute oral toxicity of capsaicin in mice and rats[J]. The Journal of toxicological sciences, 1996, 21(3): 195-200.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-10448/Capsaicin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-10448/Capsaicin-SDS-MedChemExpress.pdf

Clinical Information

Launched

CAS Number

404-86-4

Available Sizes

Curated Selection

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