Capsaicin
Capsaicin ((E) -Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer effects[1][2].
Product Specifications
CAS Number
[404-86-4]
Product Name Alternative
(E) -Capsaicin
UNSPSC
12352005
Hazard Statement
H302, H315, H318
Target
Apoptosis; Autophagy; Endogenous Metabolite; TRP Channel
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Neurological Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Capsaicin.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)
Smiles
CC(C)/C=C/CCCCC(NCC1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C18H27NO3
Molecular Weight
305.41
Precautions
H302, H315, H318
References & Citations
[1]McNamara FN, et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1) . Br J Pharmacol. 2005 Mar;144 (6) :781-90.|[2]Shin YH, et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21 (7) .|[3]Anandakumar P, et al. Capsaicin provokes apoptosis and restricts benzo (a) pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17 (2) :254-259.|[4]Nah JJ, et al. Effect of ginsenosides, active components of ginseng, on capsaicin-induced pain-related behavior. Neuropharmacology. 2000 Aug 23;39 (11) :2180-4.|[5]Joshi SK, et al Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity. Neuroscience. 2006 Dec 1;143 (2) :587-96.|[6]Pelissier T, et al. The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine. Pain. 2002 Mar;96 (1-2) :81-7.|[7]Matsuda H, et al. Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci. 1999;65 (2) :PL27-32.|[8]Demirbilek S, et al. Small-dose capsaicin reduces systemic inflammatory responses in septic rats. Anesth Analg. 2004 Nov;99 (5) :1501-1507.|[9]Friedman JR, et al. Anticancer Activity of Natural and Synthetic Capsaicin Analogs. J Pharmacol Exp Ther. 2018 Mar;364 (3) :462-473.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Citation 01
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