Mc-VC-PAB-SN38
Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38) . Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[1801838-28-7]
UNSPSC
12352203
Hazard Statement
H301, H311, H331
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-vc-pab-sn38.html
Purity
96.38
Solubility
DMSO : 28.57 mg/mL (ultrasonic)
Smiles
O=C1OCC(C2=O)=C(C=C(N2CC3=C(CC)C4=C5)C3=NC4=CC=C5O)[C@]1(CC)OC(OCC6=CC=C(C=C6)NC([C@@H](NC([C@@H](NC(CCCCCN7C(C=CC7=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O
Molecular Formula
C51H58N8O13
Molecular Weight
991.05
Precautions
H301, H311, H331
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
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