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YY173

YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1.

Product Specifications

CAS Number

330550-51-1

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yy173.html

Smiles

O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCNCC4)=NC=C2N=C1)C5CCCC5

Molecular Formula

C21H25N7O

Molecular Weight

391.47

References & Citations

[1]He H, et al., Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design. J Med Chem. 2024 Jul 11;67 (13) :11354-11364.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK4; CDK6

Frequently Asked Questions

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