(S) -AMPA

(S) -AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist[1][2].

Product Specifications

CAS Number

[83643-88-3]

Product Name Alternative

L-AMPA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-ampa.html

Purity

99.0

Solubility

H2O : 40 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(C[C@H](N)C(O)=O)=C(C)ON1

Molecular Formula

C7H10N2O4

Molecular Weight

186.17

Precautions

H302, H315, H319, H335

References & Citations

[1]J A Larm, et al. (S) -5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. Eur J Pharmacol. 1996 Oct 24;314 (1-2) :249-54.|[2]B Ebert, et al. Molecular pharmacology of the AMPA agonist, (S) -2-amino-3- (3-hydroxy-5-phenyl-4-isoxazolyl) propionic acid [ (S) -APPA] and the AMPA antagonist, (R) -APPA. Neurochem Int. 1994 Jun;24 (6) :507-15.|[3]J W Brooks, et al. (S) -AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A. Neurosci Lett. 2004 Nov 30;372 (1-2) :85-8.|[4]J A Larm, et al. Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J Neurochem. 1997 Aug;69 (2) :617-22.