(S) -AMPA
(S) -AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist[1][2].
Product Specifications
CAS Number
[83643-88-3]
Product Name Alternative
L-AMPA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-ampa.html
Purity
99.0
Solubility
H2O : 40 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(C[C@H](N)C(O)=O)=C(C)ON1
Molecular Formula
C7H10N2O4
Molecular Weight
186.17
Precautions
H302, H315, H319, H335
References & Citations
[1]J A Larm, et al. (S) -5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. Eur J Pharmacol. 1996 Oct 24;314 (1-2) :249-54.|[2]B Ebert, et al. Molecular pharmacology of the AMPA agonist, (S) -2-amino-3- (3-hydroxy-5-phenyl-4-isoxazolyl) propionic acid [ (S) -APPA] and the AMPA antagonist, (R) -APPA. Neurochem Int. 1994 Jun;24 (6) :507-15.|[3]J W Brooks, et al. (S) -AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A. Neurosci Lett. 2004 Nov 30;372 (1-2) :85-8.|[4]J A Larm, et al. Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J Neurochem. 1997 Aug;69 (2) :617-22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Available Sizes
Curated Selection
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PKM2, NT (CTHBP, Cytosolic Thyroid Hormone Binding Protein, Cytosolic Thyroid Hormone-binding Protein, OIP 3, OIP-3, Oip3, OIP3, OPA Interacting Protein 3, Opa-interacting Protein 3, P58, PK Muscle Type, PK, Muscle Type, PK2, Pk3, PKM, PYKM, Pyruvate Kinase 2/3, Pyruvate Kinase 3, Pyruvate Kinase Isozymes M1/M2, Pyruvate Kinase Muscle, Pyruvate Kinase Muscle Isozyme, Pyruvate Kinase, Muscle 2, TCB, THBP1, Thyroid Hormone Binding Protein 1, Thyroid Hormone Binding Protein Cytosolic, Thyroid Hormone-binding Protein 1, Tumor M2 PK, Tumor M2-PK)
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