A 85380 (hydrochloride)

A 85380 hydrochloride is a novel, high affinity neuronal nicotinic acetylcholine receptor (nAChR) agonist. A 85380 hydrochloride exhibits selectivity for the α4β2 nAChR subtypes. A 85380 hydrochloride has a broad-spectrum analgesic profile[1].

Product Specifications

CAS Number

[174740-86-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-85380-hydrochloride.html

Purity

97.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C1(OC[C@@H]2CCN2)=CN=CC=C1.Cl.Cl

Molecular Formula

C9H14Cl2N2O

Molecular Weight

237.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Sullivan J P, et al. A-85380 [3- (2 (S) -azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand[J]. Neuropharmacology, 1996, 35 (6) : 725-734.