JC-229
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) [1].
Product Specifications
CAS Number
[3026716-22-0]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/jc-229.html
Purity
97.07
Solubility
DMSO : 40 mg/mL (ultrasonic; adjust pH to 9 with 1M NaOH)
Smiles
O=C(NC1=CC=C(Cl)C(Cl)=C1)C2=CC=C(C)C(S(=O)(NC3=CC=C(Cl)C(Cl)=C3)=O)=C2
Molecular Formula
C20H14Cl4N2O3S
Molecular Weight
504.21
References & Citations
[1]Mukherjee A, et al. Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1. Nat Commun. 2023 Jul 20;14 (1) :4390.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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