Corticosterone
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala) . Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].
Product Specifications
CAS Number
[50-22-6]
Product Name Alternative
17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B
UNSPSC
12352211
Hazard Statement
H317
Target
Endogenous Metabolite; Glucocorticoid Receptor; iGluR
Type
Natural Products
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Corticosterone.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Molecular Formula
C21H30O4
Molecular Weight
346.47
Precautions
H317
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1618/Corticosterone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1618/Corticosterone-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
AMPA Receptor; Human Endogenous Metabolite
Available Sizes
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