AM281
AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM[1].
Product Specifications
CAS Number
202463-68-1
UNSPSC
12352005
Hazard Statement
H300, H315, H319, H335
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/am281.html
Purity
99.0
Solubility
DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(I)C=C3)=C1C)NN4CCOCC4
Molecular Formula
C21H19Cl2IN4O2
Molecular Weight
557.21
Precautions
H300, H315, H319, H335
References & Citations
[1]K S S Dossou, et al. Development and preliminary validation of a plate-based CB1/CB2 receptor functional assay. Anal Biochem. 2013 Jun 15;437 (2) :138-43.|[2]Milton, NG, et al. Effects of the CB1 cannabinoid receptor antagonist AM281 on kissorphin protection against amyloid-β neurotoxicity.|[3]G Vaseghi, et al. The effect of AM281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdrawal in mice. Res Pharm Sci. 2013 Jan;8 (1) :59-64.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1; CB2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
C9256 96 Tests
Dihydrolipoyl Dehydrogenase mitochondrial (DLD) Rabbit ELISA Kit
Sign In for Pricing
View Details MBS6451689-01 0.1 mL
STRADA (STE20-Related Kinase Adaptor alpha, FLJ90524, LYK5, NY-BR-96, PMSE, STRAD, Stlk) (HRP)
Sign In for Pricing
View Details MBS6451689-02 5x 0.1 mL
STRADA (STE20-Related Kinase Adaptor alpha, FLJ90524, LYK5, NY-BR-96, PMSE, STRAD, Stlk) (HRP)
Sign In for Pricing
View Details 
MBS9412030-01 0.1 mL
Histone H2B(Acetyl-Lys12) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details MBS9412030-02 5x 0.1 mL
Histone H2B(Acetyl-Lys12) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details