PFM01
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) [1][2].
Product Specifications
CAS Number
1558598-41-6
Product Name Alternative
Stibogluconate (trisodium nonahydrate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Endonuclease
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pfm01.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 25 mg/mL (ultrasonic)
Smiles
O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S
Molecular Formula
C14H15NO2S2
Molecular Weight
293.40
Precautions
H302, H315, H319
References & Citations
[1]Shibata A, et, al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9; 53 (1) : 7-18.|[2]Völkening L, et, al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020 Feb; 34 (2) : 2812-2820.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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