Taurolithocholic acid (sodium salt)

Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].

Product Specifications

CAS Number

[6042-32-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Endogenous Metabolite

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/taurolithocholic-acid-sodium-salt.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C

Molecular Formula

C26H44NNaO5S

Molecular Weight

505.69

Precautions

H302, H315, H319, H335

References & Citations

[1]U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29 (2) :477-82.|[2]Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278 (20) :17810-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Citation 01

Biomedicines. 2025 Apr 4;13 (4) :874.|J Transl Med. 2024 Dec 20;22 (1) :1124.|Nat Microbiol. 2024 Oct;9 (10) :2583-2599.|Nature. 2025 Jul;643 (8070) :192-200.|Adv Sci (Weinh) . 2025 Feb 3:e2411719.