Leonurine

Leonurine is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.

Product Specifications

CAS Number

[24697-74-3]

Product Name Alternative

SCM-198

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy

Type

Natural Products

Related Pathways

Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Leonurine.html

Purity

99.86

Solubility

DMSO : 30.3 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl) |H2O : < 0.1 mg/mL

Smiles

O=C(OCCCCNC(N)=N)C1=CC(OC)=C(O)C(OC)=C1

Molecular Formula

C14H21N3O5

Molecular Weight

311.33

Precautions

H315, H319, H335

References & Citations

[1]Jiang T, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43 (4) :1703-1717.|[2]Zhang L, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. Biomed Pharmacother. 2018 Dec 7;110:571-581.|[3]Hu ZC, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11.