Lipstatin

Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin ([1][2].

Product Specifications

CAS Number

[96829-59-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Lipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lipstatin.html

Purity

80.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(O[C@H](C[C@@H]([C@@H]1CCCCCC)OC1=O)C/C=C\C/C=C\CCCCC)=O)NC=O

Molecular Formula

C29H49NO5

Molecular Weight

491.70

Precautions

H315, H319, H335

References & Citations

[1]Weibel E K, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini I. Producing organism, fermentation, isolation and biological activity[J]. The Journal of antibiotics, 1987, 40 (8) : 1081-1085.|[2]Hochuli E, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation. J Antibiot (Tokyo) . 1987 Aug;40 (8) :1086-91.|[3]Weibel EK, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiot (Tokyo) . 1987 Aug;40 (8) :1081-5.