STAT3-IN-31
STAT3-IN-31 (compound K2071) is a STATtic-derived STAT3 and mitotic inhibitor. STAT3-IN-31 blocks mitotic progression and affects the formation of mitotic spindles. STAT3-IN-31 also affects glioblastoma cell migration and inhibits cell proliferation in tumor spheroids. STAT3-IN-31 is also able to induce glioblastoma senescence, inhibit the growth of Temozolomide -resistant cells and the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein MCP-1[1].
Product Specifications
UNSPSC
12352100
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-31.html
Smiles
COC1=CC=C(C=C1)CNC2=CC=C(C=CS3(=O)=O)C3=C2
Molecular Formula
C16H15NO3S
Molecular Weight
301.36
References & Citations
[1]Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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