All-trans-Anhydro Retinol

All-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342) . In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body[1][2].

Product Specifications

CAS Number

[1224-78-8]

Product Name Alternative

Anhydrovitamin A

UNSPSC

12352211

Target

Drug Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/all-trans-anhydro-retinol.html

Purity

97.01

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1(C)CCC=C(C)/C1=C/C=C(C)/C=C/C=C(C)/C=C

Molecular Formula

C20H28

Molecular Weight

268.44

References & Citations

[1]T N Varma, et al. The Utilization of Anhydrovitamin A by the Vitamin A-deficient Rat. Biochim Biophys Acta. 1965 Jun 15;104 (1) :71-7.|[2]T HIGUCHI, et al. Kinetics of Formation of Anhydrovitamin A From Vitamin A Alcohol and Its Acetate. J Am Pharm Assoc Am Pharm Assoc. 1959 Mar;48 (3) :155-61.