Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

PP58

PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values.

Product Specifications

CAS Number

[212391-58-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

FGFR; PDGFR; Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PP58.html

Concentration

10mM

Purity

98.70

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

NCCOC1=CC=C(NC(N=C2N3C)=NC=C2C=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=C1

Molecular Formula

C22H19Cl2N5O2

Molecular Weight

456.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3 (12) :1181-93.|[2]Blencke S, et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004 May;11 (5) :691-701.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-18622/PP58-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-18622/PP58-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDGFR

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Mouse Monoclonal Prostatic Acid Phosphatase/ACPP Antibody (SPM312) [Allophycocyanin]
NBP2-54475APC 100 µL

Mouse Monoclonal Prostatic Acid Phosphatase/ACPP Antibody (SPM312) [Allophycocyanin]

Ask
View Details
CHTF8 Human shRNA Lentiviral Particle (Locus ID 54921)
TL315470V 500 µL Each

CHTF8 Human shRNA Lentiviral Particle (Locus ID 54921)

Ask
View Details
Lentiviral mouse Hnrnpdl shRNA (UAS) - Lentiviral mouse Hnrnpdl shRNA (UAS, RFP) plasmid
GTR15237205 1 Vial

Lentiviral mouse Hnrnpdl shRNA (UAS) - Lentiviral mouse Hnrnpdl shRNA (UAS, RFP) plasmid

Ask
View Details
Recombinant Vibrio cholerae serotype O1 ATP synthase protein I (atpI), partial
MBS7100317 Inquire

Recombinant Vibrio cholerae serotype O1 ATP synthase protein I (atpI), partial

Ask
View Details
17:0-18:1 PG-d5
HY-146859S-01 5 mg

17:0-18:1 PG-d5

Ask
View Details
17:0-18:1 PG-d5
HY-146859S-02 1 mg

17:0-18:1 PG-d5

Ask
View Details